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Volume 32 , Issue 1
February 2012
Pages 61-67

The Negative Effect of Combining rhBMP-2 and Bio-Oss on Bone Formation for Maxillary Sinus Augmentation

Daniel W.K. Kao, DDS, MS, DMD/Atsushi Kubota, DDS/Myron Nevins, DDS/Joseph P. Fiorellini, DMD,DMSc

PMID: 22254226
DOI: 10.11607/prd.00.1038

Sinus augmentation with various bone graft materials may be required in the posterior maxilla. This study compared bone formation in a lateral window sinus augmentation with recombinant human bone morphogenetic protein 2/acellular collagen sponge (rhBMP-2/ACS) combined with Bio-Oss or Bio-Oss graft alone. Patients were assigned to treatment with either rhBMP-2/ACS + Bio-Oss or Bio-Oss alone. After a healing period, bone cores were harvested. Histologic specimens demonstrated that new bone formation was less in those who received rhBMP-2/ACS + Bio-Oss than those with Bio-Oss alone. This study indicated that the addition of rhBMP-2/ACS to Bio-Oss has a negative effect on bone formation. (Int J Periodontics Restorative Dent 2012;32:61–67.)

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